USR PUBLISHER

Inflammation disrupts normal haematological parameters, leading to anemia, immune imbalance, and systemic complications. There is a growing need for natural, plant-based alternatives like Zingiber officinale to counteract these effects safely and effectively. This study aimed to evaluate the effect of ethanol extract of Zingiber officinale on haematological parameters in male Wistar albino rats induced with inflammation. Parameters such as packed cell volume (PCV), haemoglobin (Hb), red blood cell (RBC) count, white blood cell (WBC) count, and differential leukocyte counts were assessed using an automated haematology analyzer. The results showed that inflammation caused a dose dependent decrease in PCV count (53.00 ± 0.000) in Group B when compared with the blank control (14.9 ± 0.001 g/dL) (p<0.05). The intervention of Zingiber officinale extract, returned the high dose value (14.6 ± 0.007 g/dL) to baseline (p>0.05). Other parameters such as heamaglobins, RBC, lymphocytes, eosinophils, and monocyte counts followed the same pattern as the PCV. However, the inflammation caused by white egg albumin caused dose dependent increase in WBC count (6.1 ± 0.006 ×10⁹/L) in group B when compared with the blank control (4.2 ± 0.001 ×10⁹/L) (p<0.05). However, the intervention of Zingiber officinale extract (4.3 ± 0.004 ×10⁹/L) returned it to baseline. Neutrophil, and basophil maintained the same curve as WBC. These findings indicates that Zingiber officinale ethanol extract exerts dose-dependent anti-inflammatory and hematoprotective effects by restoring PCV, Hb, RBC, WBC, and differential leukocyte levels, thereby supporting its therapeutic potential in managing inflammation-induced haematological disorders. Keywords: Zingiber officinale, haemoglobin, Inflammation, PCV, RBC, and WBC